研究業績

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原著論文（Original Article）

2025

  • Eshima H, Ishihara T, Tabuchi A, Kano Y, Kurokawa K, Shchepinov M. Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy by STZ-induced diabetic mice. Free Radic Biol Med. 2025. 230(16) 273-282. PMID: 39956472

2024

  • Hidaka K, Sonoda S, Yamaguchi T, Kose Y, Hyodo K, Oda K, Eshima H. The effects of wearing face masks on the perception and mood of healthy male adults during treadmill running: A pilot study. Physiol Rep. 2024. 12(10):e16036. PMID: 38757255
  • Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K. Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. J Clin Invest. 2024 Apr 23;134(11):e167371. PMID: 38652544
  • Shahtout JL, Eshima H, Ferrara PJ, Maschek JA, Cox JE, Drummond MJ, Funai K. Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity. J Cachexia Sarcopenia Muscle. 2024 Feb;15(1):319-330. PMID: 38123161

2023

  • Tagawa T, Eshima H, Kakehi S, Kawamori R, Watada H, Tamura Y. A chronic high-fat diet does not exacerbate muscle atrophy in fast-twitch skeletal muscle of aged mice. Exp Physiol. 2023 Jul;108(7):940-945. PMID: 37074636
  • Eshima H, Shahtout JL, Siripoksup P, Pearson MJ, Mahmassani ZS, Ferrara PJ, Lyons AW, Maschek JA, Peterlin AD, Verkerke ARP, Johnson JM, Salcedo A, Petrocelli JJ, Miranda ER, Anderson EJ, Boudina S, Ran Q, Cox JE, Drummond MJ, Funai K. Lipid hydroperoxides promote sarcopenia through carbonyl stress. (2023) Elife. 12:e85289. PMID: 36951533

2022

  • Yamamoto H, Eshima H, Kakehi S, Kawamori R, Watada H, Tamura Y. Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice. (2022). Physiol Rep. 10(18):e15478. PMID: 36117307 

2021

  • Eshima H. Influence of Obesity and Type 2 Diabetes on Calcium Handling by Skeletal Muscle: Spotlight on the Sarcoplasmic Reticulum and Mitochondria. (2021). Front Physiol. 12:758316. PMID: 34795598 
  • Ferrara PJ, Verkerke ARP, Maschek JA, Shahtout JL, Siripoksup P, Eshima H, Johnson JM, Petrocelli JJ, Mahmassani ZS, Green TD, McClung JM, Cox JE, Drummond MJ, Funai K. Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding. (2021). FASEB J. 35(10):e21867. PMID: 34499764
  • Petrocelli JJ, Mahmassani ZS, Fix DK, Montgomery JA, Reidy PT, McKenzie AI, de Hart NM, Ferrara PJ, Kelley JJ, Eshima H, Funai K, Drummond MJ. (2021). Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle. FASEB J. 35(9):e21862. PMID: 34416035
  • Ikegami R, Eshima H, Nakajima T, Toyoda S, Poole DC, Kano Y. (2021). Type I diabetes suppresses intracellular calcium ion increase normally evoked by heat stress in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 320(4):R384-R392. PMID: 33407019
  • Eshima H, Tamura Y, Kakehi S, Kakigi R, Kawamori R, Watada H. (2021). Maintenance of contractile force and increased fatigue resistance in slow-twitch skeletal muscle of mice fed a high-fat diet. J Appl Physiol. 130(3):528-536. PMID: 33270511

2020

  • Someya Y, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Eshima H, Watanabe K, Kurihara T, Yanagiya T, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Kawamori R, Watada H. (2020). Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects. Diabetes Ther. 11(10):2401-2410. PMID: 32767276 
  • Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K. (2020). Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. J Appl Physiol. 129(1):124-132. PMID: 32552434
  • Eshima H, Tamura Y, Kakehi S, Kakigi R, Hashimoto R, Funai K, Kawamori R, Watada H. (2020). A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice. J Appl Physiol.128(5):1153-1162. PMID: 32213111
  • Watanabe D, Hatakeyama K, Ikegami R, Eshima H, Yagishita K, Poole DC, Kano Y. (2020). Sex differences in mitochondrial Ca2+ handling in mouse fast-twitch skeletal muscle in vivo. J Appl Physiol.128(2):241-251. PMID: 31917626

2019

  • Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai K. (2019). Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. Nat Metab. 1(9):876-885. PMID: 32405618
  • Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. (2019). Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv. 5(9):eaax8352. PMID: 31535029
  • Tomiga Y, Ito A, Sudo M, Ando S, Eshima H, Sakai K, Nakashima S, Uehara Y, Tanaka H, Soejima H, Higaki Y. (2019). One week, but not 12 hours, of cast immobilization alters promotor DNA methylation patterns in the nNOS gene in mouse skeletal muscle. J Physiol. 597(21):5145-5159. PMID: 31490543
  • Tabuchi A, Eshima H, Tanaka Y, Nogami S, Inoue N, Sudo M, Okada H, Poole DC, Kano Y. (2019). Regional differences in Ca2+ entry along the proximal-middle-distal muscle axis during eccentric contractions in rat skeletal muscle. J Appl Physiol.127(3):828-837. PMID: 31369334
  • Hirai DM, Craig JC, Colburn TD, Eshima H, Kano Y, Musch TI, Poole DC. (2019). Skeletal muscle interstitial Po2 kinetics during recovery from contractions. J Appl Physiol. 127(4):930-939. PMID: 31369325
  • Ikegami R, Eshima H, Mashio T, Ishiguro T, Hoshino D, Poole DC, Kano Y. (2019). Accumulation of intramyocyte TRPV1-mediated calcium during heat stress is inhibited by concomitant muscle contractions. J Appl Physiol.126(3):691-698. PMID: 30676872
  • Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H. (2019). Dysfunction of muscle contraction with impaired intracellular Ca2+ handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol. 126(1):170-182. PMID: 30433865

2018

  • Hirai DM, Craig JC, Colburn TD, Eshima H, Kano Y, Sexton WL, Musch TI, Poole DC. (2018). Skeletal muscle microvascular and interstitial PO2 from rest to contractions. J Physiol. 596(5):869-883. PMID: 29288568

2017

  • Eshima H, Miura S, Senoo N, Hatakeyama K, Poole DC, Kano Y. (2017). Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α. Am J Physiol Regul Integr Comp Physiol. 312(6):R1017-R1028. PMID: 28438761
  • Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R, Okada T, Sakurai T, Kawamori R, Watada H. (2017). Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep. 5(7):e13250. PMID: 28408640
  • Wakizaka M, Eshima H, Tanaka Y, Shirakawa H, Poole DC, Kano Y. (2017). In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers. Physiol Rep. 5(5):e13180. PMID: 28292875

2015～

  • Eshima H, Poole DC, Kano Y. (2015). In vivo Ca2+ buffering capacity and microvascular oxygen pressures following muscle contractions in diabetic rat skeletal muscles: fiber-type specific effects. Am J Physiol Regul Integr Comp Physiol. 309(2):R128-37. PMID: 25947169
  • Kano Y, Miura S, Eshima H, Ezaki O, Poole DC. (2014). The effects of PGC-1α on control of microvascular P(O2) kinetics following onset of muscle contractions. J Appl Physiol. 117(2):163-70. PMID: 24833782
  • Eshima H, Tanaka Y, Sonobe T, Inagaki T, Nakajima T, Poole DC, Kano Y. (2013). In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes. Am J Physiol Regul Integr Comp Physiol. 305(6):R610-8. PMID: 23883681
総説論文（Review）
  • Eshima H. (2021). Influence of Obesity and Type 2 Diabetes on Calcium Handling by Skeletal Muscle: Spotlight on the Sarcoplasmic Reticulum and Mitochondria. Front Physiol. 12:758316. PMID: 34795598
  • Eshima H. (2020). Influence of obesity on skeletal muscle contractile dysfunction in aging. J Phys Fitness Sports Med, 9: 199-204.
  • Eshima H, Poole DC, Kano Y. (2018). Mitochondrial calcium regulation during and following contractions. J Phys Fitness Sports Med. 7: 205-211.
  • Eshima H, Poole DC, Kano Y. (2014). In vivo calcium regulation in diabetic skeletal muscle. Cell Calcium, 56(5): 381-389. PMID: 25224503 
著書（Book）
  • Hiroaki Eshima, Ikuru Miura, Yutaka Matsunaga, Yuki Tomiga, 2024年11月 Skeletal Muscle Health in Metabolic Diseases, (担当範囲:Chaptor 1, 5, 6), Bentham books, ISBN: 9789815313932
  • 江島弘晃、田村好史　2016年10月　身体活動・座位活動の科学～疫学・分子生物学から探る健康～熊谷秋三、田中茂穂、藤井宣晴（編集）　共著　羊土社出版　第7章-3